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BMS-593214 

Cat. No. M27608

All AbMole products are for research use only, cannot be used for human consumption.

BMS-593214  Structure

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Quality Control & Documentation
Biological Activity

BMS-593214 is an active site-directed factor (F) VIIa inhibitor. BMS-593214 shows antithrombotic and antihaemostatic properties. BMS-593214 is a direct competitive inhibitor of human FVIIa and a non-competitive inhibitor of Viia-activated substrate FX. BMS-593214 prevents electroinduced carotid artery thrombosis (AT) and wire induced vena cava thrombosis (VT).

Chemical Information
Molecular Weight 505.56
Formula C31H27N3O4
CAS Number 1004551-40-9
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] E Scott Priestley, et al. Bioorg Med Chem Lett. Discovery and gram-scale synthesis of BMS-593214, a potent, selective FVIIa inhibitor

[2] S Aditya. J Postgrad Med. Oral and parenteral anticoagulants: new kids on the block

[3] Antonio Gómez-Outes, et al. Ther Adv Cardiovasc Dis. New parenteral anticoagulants in development

[4] Pancras C Wong, et al. Thromb Haemost. Apixaban, a direct factor Xa inhibitor, inhibits tissue-factor induced human platelet aggregation in vitro: comparison with direct inhibitors of factor VIIa, XIa and thrombin

[5] Pancras C Wong, et al. Thromb Haemost. BMS-593214, an active site-directed factor VIIa inhibitor: enzyme kinetics, antithrombotic and antihaemostatic studies

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Abmole Inhibitor Catalog




Keywords: BMS-593214  supplier, inhibitors, activators

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