BMS 204352 is a potassium channel modulator. Originally developed as a potent opener of large-conductance, calcium-activated (Maxi-K, KCa1.1, BK) potassium channels, BMS 204352 also acts as a positive modulator at Kv7 (KCNQ) channels.
Molecular Weight | 359.7 |
Formula | C16H10ClF4NO2 |
CAS Number | 187523-35-9 |
Solubility (25°C) | DMSO: 20 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[1] Rikke Louise Schrder, et al. Voltage-independent KCNQ4 currents induced by (+/-)BMS-204352
[2] Bo Skaaning Jensen. BMS-204352: a potassium channel opener developed for the treatment of stroke
[4] K B Mackay. BMS-204352 (Bristol Myers Squibb)
[5] R L Schrder, et al. KCNQ4 channel activation by BMS-204352 and retigabine
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