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Bmp-7 protein, Human (E. coli)

Cat. No. M11480
Bmp-7 protein, Human (E. coli) Structure
Synonym:

Bone morphogenetic protein 7

Size Price Availability Quantity
10 μg USD 280  USD280 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin < 0.2 EU/μg
  • COA
  • MSDS
Biological Activity

Molecular weight: about 15.7 kDa
Endotoxin <0.2 EU/μg was determined by LAL method.
Composition: lyophilized after extensive dialysis in 30% acetonitrile, 0.1% TFA solution.
Purity: SDS-PAGE > 95% HPLC analysis of 95%
Stability and storage: store at -20°C. After recombination, it can be stabilized at 4℃ for 1 week or -20℃ for a longer time. It is recommended to freeze storage at -20 ° C or -80 ° C to prolong storage time.


Biological activity: Bone Morphogenetic protein-7 (BMP-7)  (E. coli) is a homodimer glycoprotein belonging to the transforming growth factor β (TGFβ) superfamily, which plays a role in osteogenesis and chondrogenesis. It is involved in a variety of cellular processes including kidney and eye development, brown fat formation and bone metastasis.


Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin < 0.2 EU/μg
Solubility
Storage at -20°C
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Keywords: Bmp-7 protein, Human (E. coli), Bone morphogenetic protein 7 supplier, Cytokines, inhibitors

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