All AbMole products are for research use only, cannot be used for human consumption.
Recombinant Human Bone Morphogenetic Protein-2 (BMP-2) is a bone-growth regulatory factor and belongs to the transforming growth factor-beta (TGF-beta) superfamily. Human Bone Morphogenetic Protein-2 (BMP-2) is synthesized as large precursor molecule (Met1-Arg396, with a signal peptide from Met1 to Gly23), propeptide (Leu24-Arg282) of which is cleaved by PCSK5 (Proprotein Convertase Subtilisin/Kexin type 5). BMP-2 plays an important role in the development of bone and cartilage, cardiac cell differentiation and epithelial to mesenchymal transition. It is also involved in the hedgehog pathway, TGF-beta signaling pathway, and in cytokine-cytokine receptor interaction.
Measured by its ability to induce alkaline phosphatase production by ATDC-5 Cells, the ED50 for this effect is typically 0.07-0.2 µg/ml.
Measured by its ability to induce alkaline phosphatase production by C2C12 cells, the ED50 for this effect is typically 0.2-1 µg/ml.
Accession: # P12643
Apparent Molecular Weight: ~26 kDa, on SDS-PAGE under non-reducing conditions.
Lyophilized after extensive dialysis against 50 mM acetic acid.
J Gastroenterol Hepatol. 2025 Mar 26.
The Role of BMP2/4 in Intestinal Ischemia‐Reperfusion Injury: Bridging Smad1/5 and Notch Pathways via Smad6
Recombinant Human BMP-2 (E.coli) purchased from AbMole
| Solubility (25°C) | Reconstitute the lyophilized powder in 20 mM AcOH or 5 mM HCl up to 100 μg/ml. |
| Storage | Stable for up to 6 months at lower than -70°C |
[4] Branko Skovrlj, et al. Spine (Phila Pa 1976). Association Between BMP-2 and Carcinogenicity
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| Recombinant Human FGFR1 Protein (HEK293, C-His)
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| Recombinant Human FGFR2 Protein (HEK293, C-His)
FGFR2, also known as CD332, acts as cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. FGFR2 plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. It also promotes cell proliferation in keratinocytes and imature osteoblasts, but promotes apoptosis in differentiated osteoblasts. |
| Recombinant Mouse BMP-4 Protein (E. coli, C-His)
Bone Morphogenetic Protein-4 (BMP-4) is a critical signaling molecule required for the early differentiation of the embryo and establishing of a dorsal-ventral axis. BMP-4 is secreted from the dorsal portion of the notochord, and it acts in concert with sonic hedgehog to establish a dorsal-ventral axis for the differentiation of later structures. |
| Recombinant Human Coagulation Factor X (HEK293, C-Fc)
Coagulation factor X, belongs to the peptidase S1 family. Coagulation factor X is initially synthesized in the liver. Coagulation factor X is a vitamin K-dependent glycoprotein that converts prothrombin to thrombin in the presence of factor Va, calcium and phospholipid during blood clotting. |
All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.
Products are for research use only. Not for human use. We do not sell to patients.
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