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BM212

Cat. No. M21923

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BM212 Structure
Size Price Availability Quantity
5mg USD 135  USD135 In stock
10mg USD 216  USD216 In stock
25mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

BM212 is a potent Mycobacterial membrane protein Large 3 (MmpL3) inhibitor. BM212 has strong bactericidal activity against both M. tuberculosis and some nontuberculosis mycobacteria. BM212 exhibits antimycobacterial activity against M. tuberculosis H37Rv with an MIC of 5 µM.

Chemical Information
Molecular Weight 414.37
Formula C23H25Cl2N3
CAS Number 146204-42-4
Solubility (25°C) Ethanol 4.5 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Alice R Moorey, et al. Cell Surf. The multi-target aspect of an MmpL3 inhibitor: The BM212 series of compounds bind EthR2, a transcriptional regulator of ethionamide activation

[2] Giovanna Poce, et al. PLoS One. Improved BM212 MmpL3 inhibitor analogue shows efficacy in acute murine model of tuberculosis infection

[3] Valentina La Rosa, et al. Antimicrob Agents Chemother. MmpL3 is the cellular target of the antitubercular pyrrole derivative BM212

[4] M Biava, et al. Mini Rev Med Chem. New derivatives of BM212: A class of antimycobacterial compounds based on the pyrrole ring as a scaffold

[5] Mariangela Biava, et al. Bioorg Med Chem. Antimycobacterial compounds. New pyrrole derivatives of BM212

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Keywords: BM212 supplier, Antibiotic, inhibitors, activators

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