Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
 Seonaidh Cotton, et al. Trials. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)
 L Muresan, et al. Ann Pharm Fr. Beta-blockers for the treatment of arrhythmias: Bisoprolol - a systematic review
 Celia Castao-Amores, et al. Biomed Pharmacother. Pharmacogenetic polymorphisms affecting bisoprolol response
 Ahmed H Bakheit, et al. Profiles Drug Subst Excip Relat Methodol. Bisoprolol: A comprehensive profile
 Dipak Kotecha, et al. JAMA. Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial
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