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Bisoprolol

Cat. No. M20992
Bisoprolol Structure
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Biological Activity

Bisoprolol is a cardioselective β1-adrenergic blocking agent used for secondary prevention of myocardial infarction (MI), heart failure, angina pectoris and mild to moderate hypertension.

Chemical Information
Molecular Weight 325.44
Formula C18H31NO4
CAS Number 66722-44-9
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Seonaidh Cotton, et al. Trials. Use of the oral beta blocker bisoprolol to reduce the rate of exacerbation in people with chronic obstructive pulmonary disease (COPD): a randomised controlled trial (BICS)

[2] L Muresan, et al. Ann Pharm Fr. Beta-blockers for the treatment of arrhythmias: Bisoprolol - a systematic review

[3] Celia Castao-Amores, et al. Biomed Pharmacother. Pharmacogenetic polymorphisms affecting bisoprolol response

[4] Ahmed H Bakheit, et al. Profiles Drug Subst Excip Relat Methodol. Bisoprolol: A comprehensive profile

[5] Dipak Kotecha, et al. JAMA. Effect of Digoxin vs Bisoprolol for Heart Rate Control in Atrial Fibrillation on Patient-Reported Quality of Life: The RATE-AF Randomized Clinical Trial

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