Free shipping on all orders over $ 500

Bisandrographolide C

Cat. No. M28657

All AbMole products are for research use only, cannot be used for human consumption.

Bisandrographolide C Structure

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Bisandrographolide C is an unusual dimer of ent-labdane diterpenoid isolated and identified from Andrographis paniculata. Bisandrographolide C activates TRPV1 and TRPV3 channels with Kd values of 289 and 341 μM respectively, and protects cardiomyocytes from hypoxia-reoxygenation injury.

Chemical Information
Molecular Weight 664.87
Formula C40H56O8
CAS Number 160498-02-2
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Grace Gar-Lee Yue, et al. Phytomedicine. Identification of active components in Andrographis paniculata targeting on CD81 in esophageal cancer in vitro and in vivo

[2] Sharma Pooja Tarachand, et al. J Biomol Struct Dyn. In silico molecular docking study of Andrographis paniculata phytochemicals against TNF-α as a potent anti-rheumatoid drug

[3] Suyu Gao, et al. J Org Chem. Unusual ent-Labdane Diterpenoid Dimers and their Selective Activation of TRPV Channels

[4] Joris Vriens, et al. J Biol Chem. Determinants of 4 alpha-phorbol sensitivity in transmembrane domains 3 and 4 of the cation channel TRPV4

Related TRP Channel Products
Moringin

Moringin is a potent and selective TRPA1 ion channel natural agonist with an EC50 of 3.14 μM. Moringin does not activate or activates very weakly the vanilloids somatosensory channels TRPV1, TRPV2, TRPV3 and TRPV4, and the melastatin cooling receptor TRPM8.

(S)-ABT-102

(S)-ABT-102 is a potent TRPV1 antagonist, with an IC50 of 123 nM. (S)-ABT-102 can block the activation of TRPV1 by capsaicin.
Oleoyl Serotonin

Oleoyl Serotonin is a TRPV1 antagonist with IC50 value of 2.57 μM for human TRPV1.
ABT-102

ABT-102 (CHEMBL398338) is a potent and highly selective transient receptor potential vanilloid 1 (TRPV1) receptor antagonist.

MK-2295

MK-2295 (TRPV1 antagonist 5) is a potent TRPV1 antagonist. MK-2295 can be used for the research of chronic pain.
  Catalog
Abmole Inhibitor Catalog




Keywords: Bisandrographolide C supplier, TRP Channel, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.