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Bintrafusp alfa

Cat. No. M24850
Bintrafusp alfa Structure
Synonym:

M 7824; MSB0011359C

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Quality Control & Documentation
Biological Activity

Bintrafusp alfa (M 7824) is a first-in-class bifunctional fusion protein composed of the extracellular domain of TGF-βRII fused to a human IgG1 mAb blocking programmed cell death ligand. Bintrafusp alfa can be used for the research of cancer.

Chemical Information
CAS Number 1918149-01-5
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yan Lan, et al. J Immunother Cancer. Colocalized targeting of TGF-β and PD-L1 by bintrafusp alfa elicits distinct antitumor responses

[2] Sofia R Gameiro, et al. Exp Biol Med (Maywood). Preclinical and clinical studies of bintrafusp alfa, a novel bifunctional anti-PD-L1/TGFβRII agent: Current status

[3] Benjamin Tan, et al. Target Oncol. Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Patients with Esophageal Adenocarcinoma: Results from a Phase 1 Cohort

[4] Jiasheng Xu, et al. J Thorac Oncol. Bintrafusp Alfa in the Second-Line Treatment of Patients With NSCLC

[5] Luis Paz-Ares, et al. J Thorac Oncol. Bintrafusp Alfa, a Bifunctional Fusion Protein Targeting TGF-β and PD-L1, in Second-Line Treatment of Patients With NSCLC: Results From an Expansion Cohort of a Phase 1 Trial

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Keywords: Bintrafusp alfa, M 7824; MSB0011359C supplier, TGF-beta/Smad, inhibitors, activators


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