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BILN 2061

Cat. No. M3630
BILN 2061 Structure
Synonym:

Ciluprevir, BILN 2061ZW

Size Price Availability
5mg USD 650  USD650 Out of stock
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Quality Control & Documentation
Biological Activity

BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM. BILN 2061 is useful for Anti HCV.

Chemical Information
Molecular Weight 774.93
Formula C40H50N6O8S
CAS Number 300832-84-2
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Stoltz JH, et al. Toxicol Pathol. A twenty-eight-day mechanistic time course study in the rhesus monkey with hepatitis C virus protease inhibitor BILN 2061.

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Keywords: BILN 2061, Ciluprevir, BILN 2061ZW supplier, HCV Protease, inhibitors, activators


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