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BILN 2061

Cat. No. M3630
BILN 2061 Structure
Synonym:

Ciluprevir, BILN 2061ZW

Size Price Availability
5mg USD 585  USD650 Out of stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

BILN 2061 is a specific and potent peptidomimetic inhibitor of the HCV NS3 protease with IC50 of 3.0 nM. BILN 2061 is useful for Anti HCV.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 774.93
Formula C40H50N6O8S
CAS Number 300832-84-2
Purity >98%
Solubility DMSO
Storage at -20°C
References

A twenty-eight-day mechanistic time course study in the rhesus monkey with hepatitis C virus protease inhibitor BILN 2061.
Stoltz JH, et al. Toxicol Pathol. 2011 Apr;39(3):496-501. PMID: 21441227.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: BILN 2061, Ciluprevir, BILN 2061ZW supplier, HCV Protease, inhibitors

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