Free shipping on all orders over $ 500

Bigelovin

Cat. No. M11052
Bigelovin  Structure
Size Price Availability Quantity
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control & Documentation
Biological Activity

Bigelovin is a sesquiterpene lactone isolated from sea lilies and is an α agonist of the selective retinoid X receptor α. Bigelovin exerts antitumor activity by inducing apoptosis and autophagy. Bigelovin regulates the mTOR signal path by suppressing the generation of ROS.

Chemical Information
Molecular Weight 304.3377
Formula C17H20O5
CAS Number 3668-14-2
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage 4°C, protect from light, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Yuan Feng, et al. Anticancer Drugs. Sesquiterpene lactone Bigelovin induces apoptosis of colon cancer cells through inducing IKK-β degradation and suppressing nuclear factor kappa B activation

[2] Bei Wang, et al. Biochem Biophys Res Commun. Bigelovin, a sesquiterpene lactone, suppresses tumor growth through inducing apoptosis and autophagy via the inhibition of mTOR pathway regulated by ROS generation in liver cancer

[3] Mingyue Li, et al. Biochem Pharmacol. Natural small molecule bigelovin suppresses orthotopic colorectal tumor growth and inhibits colorectal cancer metastasis via IL6/STAT3 pathway

[4] Mingyue Li, et al. Sci Rep. Bigelovin triggered apoptosis in colorectal cancer in vitro and in vivo via upregulating death receptor 5 and reactive oxidative species

[5] Hao-hao Zhang, et al. Acta Pharmacol Sin. Bigelovin inhibits STAT3 signaling by inactivating JAK2 and induces apoptosis in human cancer cells

Related RAR/RXR Products
MSU-42011

MSU-42011 is an orally active retinoid X receptor-like (RXR) agonist that potently inhibits the expression of iNOS as well as p-ERK protein levels. In addition, MSU-42011 has immunomodulatory and antitumor activities for cancer research.

KCL-286

KCL-286 is an orally active retinoic acid receptor-beta (RAR-beta) agonist for studies related to spinal cord injury.

XS-060

XS-060 is a potent anticancer agent and RXRα antagonist.

BPA-B9

BPA-B9 is a RXRα ligand and antagonist targeting the pRXRα-PLK1 interaction.

ER 50891 quarterhydrate

ER 50891 quarterhydrate is a potent antagonist of retinoic acid receptor α(RARα).

  Catalog
Abmole Inhibitor Catalog




Keywords: Bigelovin supplier, RAR/RXR, inhibitors, activators


Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.