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Bexarotene

Cat. No. M5455
Bexarotene Structure
Synonym:

LGD1069

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM/1mL In DMSO USD 85 In stock
50mg USD 70 In stock
100mg USD 105 In stock
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Quality Control
Biological Activity

Bexarotene is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 348
Formula C24H28O2
CAS Number 153559-49-0
Purity >99%
Solubility 8 mg/mL in DMSO
Storage at -20°C
References

Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.
Mounier A, et al. J Neurosci. 2015 Aug 26;35(34):11862-76. PMID: 26311769.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Bexarotene, LGD1069 supplier, RAR/RXR, inhibitors

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