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Bexarotene

Cat. No. M5455
Bexarotene Structure
Synonym:

LGD1069

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 45  USD45 In stock
25mg USD 40  USD40 In stock
50mg USD 60  USD60 In stock
100mg USD 95  USD95 In stock
500mg USD 285  USD285 In stock
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Quality Control & Documentation
Biological Activity

Bexarotene (LGD1069) is a retinoid specifically selective for retinoid X receptors, used as an oral antineoplastic agent in the treatment of cutaneous T-cell lymphoma.

Chemical Information
Molecular Weight 348
Formula C24H28O2
CAS Number 153559-49-0
Solubility (25°C) DMSO ≥ 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Mounier A, et al. J Neurosci. Bexarotene-Activated Retinoid X Receptors Regulate Neuronal Differentiation and Dendritic Complexity.

[2] Y Li, et al. Br J Cancer . The rexinoid, bexarotene, prevents the development of premalignant lesions in MMTV-erbB2 mice

[3] Y Wang, et al. Oncogene . Prevention of lung cancer progression by bexarotene in mouse models

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