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Bethanechol chloride is a selective muscarinic receptor agonist without any effect on nicotinic receptors. Bethanechol chloride (0.3-300 μM) significantly reduces ileal pacemaker potentials. It is a parasympathomimetic choline ester. It is not hydrolyzed by cholinesterase and will therefore have a long duration of action. It does not involve the action of the muscarinic M3 receptor subtype in-vitro. Bethanechol (2-12 mg/kg; i.p.) induces drinking and increases urine output of rats in a dose-dependent fashion.
| Molecular Weight | 196.68 |
| Formula | C7H17N2O2.Cl |
| CAS Number | 590-63-6 |
| Solubility (25°C) | DMSO 10 mg/mL Water 40 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] J L Schlatter, et al. Bethanechol chloride oral solutions: stability and use in infants
[4] J K Light, et al. Bethanechol chloride and the traumatic cord bladder
| Related AChR/AChE Products |
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| Methoctramine tetrahydrochloride
Methoctramine tetrahydrochloride is a potent and cardioselectivity antagonist of M2 muscarinic receptor. |
| AT 1001
AT 1001 is a high-affinity and selective antagonist of the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) with Ki of 2.64 nM. |
| Dihydro-β-erythroidine hydrobromide
Dihydro-β-erythroidine hydrobromide is a potent, orally active, and competitive antagonist of neuronal nAChRs. Dihydro-β-erythroidine hydrobromide shows selectivity for α4β4 and α4β2 nAChRs, with IC50s of 0.19 and 0.37 μM, respectively. |
| Spinosad
Spinosad, a mixture of spinosyns A and D known as fermentation products of a soil actinomycete (Saccharopolyspora spinosa), is a biological neurotoxic insecticide with a broader action spectrum. Spinosad targets the nicotinic acetylcholine receptor (nAChRs) of the insect nervous system. |
| TAE-1
TAE-1 is a potent inhibitor of AChE and BuChE. |
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