Free shipping on all orders over $ 500

Bergaptol

Cat. No. M10656
Bergaptol Structure
Synonym:

4-Hydroxybergapten; 5-Hydroxypsoralen

Size Price Availability Quantity
5mg USD 150  USD150 In stock
10mg USD 210  USD210 In stock
Free Delivery on orders over USD 500 Bulk Inquiry?

Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Bergaptol is a hydroxylated psoralen that acts as a potent inhibitors of debenzylation activity of CYP3A4 enzyme with an IC50 value of 24.92 uM.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 202.16
Formula C11H6O4
CAS Number 486-60-2
Purity >99%
Solubility DMSO 30 mg/mL
Storage 2-8°C, dry, sealed
References

[1] Chun-Yan Shen, et al. Food Funct. Bergaptol from blossoms of Citrus aurantium L. var. amara Engl inhibits LPS-induced inflammatory responses and ox-LDL-induced lipid deposition

[2] Yucheng Zhao, et al. J Adv Res. Structure-based tailoring of the first coumarins-specific bergaptol O-methyltransferase to synthesize bergapten for depigmentation disorder treatment

[3] Yucheng Zhao, et al. Front Plant Sci. Cloning, Functional Characterization, and Catalytic Mechanism of a Bergaptol O-Methyltransferase from Peucedanum praeruptorum Dunn

[4] Aya Ishikawa, et al. Plant Cell Rep. Constitutive expression of bergaptol O-methyltransferase in Glehnia littoralis cell cultures

[5] G RODIGHIERO, et al. Farmaco Sci. [Bergaptol ethers]

Related Cytochrome P450 (e.g. CYP17) Products
Naringin

Naringin, a flavanone glycoside, exerts various of pharmacological effects such as blood lipid lowering, antioxidant activity, anticancer activity, and inhibition of cytochrome P450 enzymes.

Tebuconazole

Tebuconazole is an agricultural azole fungicide that also inhibits CYP51 for Candida albicans CYP51 (CaCYP51) and truncated human CYP51 (Δ60HsCYP51). IC50 The values are 0.9 and 1.3 μM, respectively.

Uniconazole

Uniconazole is a plant growth regulator that inhibits cytochrome P450 707As (Ki=68 nM) plays a role, which is a family of enzymes that separate abscisic acid and therefore inhibits the biosynthesis of gibberellin and sterols.

Dihydromethysticin

Dihydroestherol (Dihydromethysticin) kava lactone, with induced CYP3A23 activity.

ε-​Viniferin

ε-Viniferin is a potent inhibitor for all the CYP family, with Ki values from 0.5-20 μM.

  Catalog
Abmole Inhibitor Catalog




Keywords: Bergaptol, 4-Hydroxybergapten; 5-Hydroxypsoralen supplier, Cytochrome P450 (e.g. CYP17), inhibitors

Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.