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Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity. Berberine is also an AMPK activator.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | 336.36 |
| Formula | C20H18NO4 |
| CAS Number | 2086-83-1 |
| Purity | ≥99% |
| Solubility | DMSO: 27 mg/mL |
| Storage | at -20°C |
Berberine induces apoptosis and DNA damage in MG‑63 human osteosarcoma cells
Yu Zhu, et al. Mol Med Rep. 2014 Oct;10(4):1734-8. PMID: 25050485.
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