Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity. Berberine is also an AMPK activator.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Solubility||DMSO: 27 mg/mL|
|Related Wnt/beta-catenin Products|
NLS-StAx-h is a selective fixed peptide inhibitor of Wnt signaling,IC50 1.4 μM.
Methyl vanillate, an extract found in the genus Loquat, is a Wnt/β-catenin signaling pathway activator. Benzoate, is the methyl ester of vanillin. It has antioxidant effects. Plant metabolites.
L-Quebrachitol is a natural product isolated from a variety of plants that promotes osteoblast production by upregulating BMP-2, runt-associated transcription factor (Runx2), MAPK (ERK, JNK, p38α), and Wnt/β-catenin signaling pathways.
PRI-724 (C-82 prodrug, ICG-001 analog) is a potent, specific inhibitor that disrupts the interaction of β-catenin and CBP
Foxy-5 TFA, a WNT5A agonist, is a mimicking peptide of WNT5A which is a non-canonical member of the Wnt family. Foxy-5 TFA triggers cytosolic free calcium signaling without affecting β-catenin activation and it impairs the migration and invasion of epithelial cancer cells.
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.