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Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity. Berberine is also an AMPK activator. Berberine induces reactive oxygen species (ROS) generation and inhibits DNA topoisomerase.
Chem Biol Drug Des. 2025 Apr 29;105(4):e70111.
Berberine Ameliorates Pulmonary Fibrosis by Inactivating the Thrombospondin 2/Smad Homolog 2/3 Pathway
Berberine purchased from AbMole
| Cell Experiment | |
|---|---|
| Cell lines | M2 cells |
| Preparation method | For time-course studies, Berberine wasadded to 100 μM to dishes of M2 cells 360, 300, 240, 180, 120, 60 and 30 min prior to harvesting by trypsinization. |
| Concentrations | 100 μM |
| Incubation time | 360, 300, 240, 180, 120, 60 and 30 min |
| Animal Experiment | |
|---|---|
| Animal models | Adult male Swiss albino mice |
| Formulation | DMSO and 0.9% saline |
| Dosages | 5, 10 or 20 mg/kg |
| Administration | Intraperitoneal injection |
| Molecular Weight | 336.36 |
| Formula | C20H18NO4 |
| CAS Number | 2086-83-1 |
| Solubility (25°C) | DMSO 25 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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