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Berberine

Cat. No. M9168
Berberine Structure
Size Price Availability Quantity
5mg USD 36  USD40 In stock
10mg USD 54  USD60 In stock
50mg USD 108  USD120 In stock
100mg USD 162  USD180 In stock
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Quality Control
  • Current batch:
  • Purity ≥99%
  • COA
  • MSDS
Biological Activity

Berberine is an alkaloid in several plants with various biological functions, including insulin-sensitizing, anti-inflammatory, and anti-oxidant activity. Berberine is also an AMPK activator.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 336.36
Formula C20H18NO4
CAS Number 2086-83-1
Purity ≥99%
Solubility DMSO: 27 mg/mL
Storage at -20°C
References

Berberine induces apoptosis and DNA damage in MG‑63 human osteosarcoma cells
Yu Zhu, et al. Mol Med Rep. 2014 Oct;10(4):1734-8. PMID: 25050485.

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Keywords: Berberine supplier, Wnt/beta-catenin, inhibitors

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