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Bepirovirsen

Cat. No. M21622
Bepirovirsen Structure
Synonym:

GSK3228836; GSK836; BPV

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Biological Activity

Bepirovirsen is an antisense oligonucleotide targeting all HBV messenger RNAs. Bepirovirsen leads to reductions in HBV-derived RNAs, HBV DNA and viral proteins.

Chemical Information
Molecular Weight 7344.0
CAS Number 1403787-62-1
Solubility (25°C) N/A
Storage 4°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Sabela Lens. Gastroenterology. Bepirovirsen-A New Therapy for Chronic Hepatitis B Infection

[2] Man-Fung Yuen, et al. N Engl J Med. Efficacy and Safety of Bepirovirsen in Chronic Hepatitis B Infection

[3] Andrew Vaillant. J Hepatol. Bepirovirsen/GSK3389404: Antisense or TLR9 agonists?

[4] Eleni Kotsiliti. Nat Rev Gastroenterol Hepatol. Bepirovirsen assessment in chronic hepatitis B

[5] Man-Fung Yuen, et al. Nat Med. Safety, tolerability and antiviral activity of the antisense oligonucleotide bepirovirsen in patients with chronic hepatitis B: a phase 2 randomized controlled trial

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Keywords: Bepirovirsen, GSK3228836; GSK836; BPV supplier, inhibitors, activators


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