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Bentracimab

Cat. No. M25062

All AbMole products are for research use only, cannot be used for human consumption.

Bentracimab Structure
Synonym:

PB 2452; MEDI 2452

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Quality Control & Documentation
Biological Activity

Bentracimab (PB 2452) is a neutralizing monoclonal antibody that binds Ticagrelor and its major active circulating metabolite with high affinity. Bentracimab can rapidly reverse the antiplatelet effect of Ticagrelor.

Chemical Information
CAS Number 2260568-31-6
Storage Please store the product under the recommended conditions in the Certificate of Analysis.
References

[1] Luis Ortega-Paz, et al. Clin Pharmacokinet. Clinical and Pre-Clinical Pharmacokinetics and Pharmacodynamics of Bentracimab

[2] Steven J Kathman, et al. CPT Pharmacometrics Syst Pharmacol. Population pharmacokinetic-pharmacodynamic modeling of PB2452, a monoclonal antibody fragment being developed as a ticagrelor reversal agent, in healthy volunteers

[3] Ahmad Makhdoum, et al. J Card Surg. Ticagrelor use and practice patterns among Canadian cardiac surgeons

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Keywords: Bentracimab, PB 2452; MEDI 2452 supplier, inhibitors, activators

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