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Benpyrine racemate

Cat. No. M10643
Benpyrine racemate Structure
Synonym:

(Rac)-Benpyrine

Size Price Availability Quantity
5mg USD 175  USD175 In stock
10mg USD 280  USD280 In stock
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Quality Control
  • Current batch:
  • Purity >99%
  • COA
  • MSDS
Biological Activity

Benpyrine racemate ((Rac)-Benpyrine) is a racemate of Benpyrine, Benpyrine racemate ((Rac)-Benpyrine) is a potent and orally active TNF-α inhibitor and has the potential for TNF-α mediated inflammatory and autoimmune disease research. (Rac)-Benpyrine (5-10 μM; 24 hours) treatment inhibits the expression level of TNF-α downstream pathway protein NF-κB in the nucleus in RAW264.7 macrophages. In vivo, (Rac)-Benpyrine (25-50 mg/kg/day; oral gavage; 3 weeks) treatment obviously reduces the inflammatory cytokines IFN-γ, IL-1β and IL-6 in the blood serum, and the anti-inflammatory factor IL-10 is obviously increased, the foot swelling degree of the arthritis part is also obviously slowed down.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 308.34
Formula C16H16N6O
CAS Number 1333714-43-4
Purity >99%
Solubility DMSO 9 mg/mL
Storage 2-8°C, protect from light, sealed
References

[1] Weiguang Sun, et al. J Med Chem . Discovery of an Orally Active Small-Molecule Tumor Necrosis Factor-α Inhibitor

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Benpyrine racemate, (Rac)-Benpyrine supplier, TNF-alpha, inhibitors

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