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Bemnifosbuvir hemisulfate (AT-527) is a guanosine nucleotide prodrug and a potent orally active inhibitor of HCV viral replication. Bemnifosbuvir hemisulfate effectively inhibits SARS-CoV-2 (COVID-19) infection (EC90=0.47 μM). Bemnifosbuvir hemisulfate has whole-genotype antiviral activity. In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.
| Molecular Weight | 630.58 |
| Formula | C24H33FN7O7P.1/2(H2O4S) |
| CAS Number | 2241337-84-6 |
| Solubility (25°C) | DMSO ≥ 130 mg/mL Water 100 mg/mL |
| Storage | 4°C, dry, sealed |
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