Bemnifosbuvir hemisulfate (AT-527) is a guanosine nucleotide prodrug and a potent orally active inhibitor of HCV viral replication. Bemnifosbuvir hemisulfate effectively inhibits SARS-CoV-2 (COVID-19) infection (EC90=0.47 μM). Bemnifosbuvir hemisulfate has whole-genotype antiviral activity. In normal human airway epithelial cells, the concentration of Bemnifosbuvir hemisulfate required to inhibit replication of SARS-CoV-2 by EC90 is 0.47 μM, very similar to its EC90 against HCoV-229E, HCoV-OC43 and SARS-CoV in Huh-7 cells.
Molecular Weight | 630.58 |
Formula | C24H33FN7O7P.1/2(H2O4S) |
CAS Number | 2241337-84-6 |
Solubility (25°C) | DMSO ≥ 130 mg/mL Water 100 mg/mL |
Storage | 4°C, dry, sealed |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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