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BAY 80-6946

Cat. No. M2436
BAY 80-6946  Structure
Synonym:

Copanlisib

Size Price Availability Quantity
2mg USD 50  USD50 In stock
5mg USD 80  USD80 In stock
10mg USD 120  USD120 In stock
50mg USD 330  USD330 In stock
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Quality Control & Documentation
Biological Activity

BAY 80-6946 is a potent and highly selective reversible PI3K inhibitor for PI3Kα/β with IC50 of 0.469 nM/3.72 nM.

Chemical Information
Molecular Weight 480.52
Formula C23H28N8O4
CAS Number 1032568-63-0
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Liguo Wang, et al. Discovery of a first-in-class CDK2 selective degrader for AML differentiation therapy

[2] Michael Northend, et al. Novel Therapy Approaches to Follicular Lymphoma

[3] Ariel Sindel, et al. Marginal Zone Lymphoma: State-of-the-Art Treatment

[4] Marc Sorigue, et al. Recent landmark studies in follicular lymphoma

[5] Ningshu Liu, et al. BAY 80-6946 is a highly selective intravenous PI3K inhibitor with potent p110α and p110δ activities in tumor cell lines and xenograft models

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  Catalog
Abmole Inhibitor Catalog




Keywords: BAY 80-6946 , Copanlisib supplier, PI3K, inhibitors, activators


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