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BAY-678

Cat. No. M8577

All AbMole products are for research use only, cannot be used for human consumption.

BAY-678 Structure

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Quality Control & Documentation
Biological Activity

BAY-678 is an orally available, highly potent and selective inhibitor of human neutrophil elastase (HNE). For full characterization details, please visit the BAY-678 probe summary on the Structural Genomics Consortium (SGC) website.

To learn about other SGC chemical probes for protein targets, visit sigma.com/sgc

Chemical Information
Molecular Weight 400.35
Formula C20H15F3N4O2
CAS Number 675103-36-3
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Franz von Nussbaum, et al. Potent and Selective Human Neutrophil Elastase Inhibitors with Novel Equatorial Ring Topology: in vivo Efficacy of the Polar Pyrimidopyridazine BAY-8040 in a Pulmonary Arterial Hypertension Rat Model

[2] Franz von Nussbaum, et al. Freezing the Bioactive Conformation to Boost Potency: The Identification of BAY 85-8501, a Selective and Potent Inhibitor of Human Neutrophil Elastase for Pulmonary Diseases

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Keywords: BAY-678 supplier, inhibitors, activators

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