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Bavachinin

Cat. No. M5169

All AbMole products are for research use only, cannot be used for human consumption.

Bavachinin Structure
Synonym:

7-O-Methylbavachin; Bavachinin A

Size Price Availability Quantity
5mg USD 55  USD55 In stock
10mg USD 80  USD80 In stock
20mg USD 120  USD120 In stock
100mg USD 280  USD280 In stock
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Quality Control & Documentation
Biological Activity

In vitro: Isobavachalcone significantly inhibits both oligomerization and fibrillization of Aβ42, whereas bavachinin inhibits fibrillization and leads to off-pathway aggregation. Both of the compounds attenuated Aβ42-induced toxicity in a SH-SY5Y cell model. Bavachinin, has potent anti-angiogenic activity in vitro and in vivo. Bavachinin inhibited increases in HIF-1α activity in human KB carcinoma (HeLa cell derivative) and human HOS osteosarcoma cells under hypoxia in a concentration-dependent manner, probably by enhancing the interaction between von Hippel-Lindau (VHL) and HIF-1α. In vivo: significantly inhibited Th2 cytokine production, including IL-4, IL-5 and IL-13. Notably, this compound almost completely blocked inflammation in the ovalbumin (OVA)-sensitized animal asthma model.

Protocol (for reference only)
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models female db/db mice
Formulation
Dosages 100mg/kg/day
Administration gavage
Chemical Information
Molecular Weight 338.4
Formula C21H22O4
CAS Number 19879-30-2
Form Solid
Solubility (25°C) DMSO 40 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Feng L, et al. Diabetologia. Bavachinin, as a novel natural pan-PPAR agonist, exhibits unique synergistic effects with synthetic PPAR-γ and PPAR-α agonists on carbohydrate and lipid metabolism in db/db and diet-induced obese mice.

[2] Chen X, et al. FEBS Lett. Isobavachalcone and bavachinin from Psoraleae Fructus modulate Aβ42 aggregation process through different mechanisms in vitro.

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Keywords: Bavachinin, 7-O-Methylbavachin; Bavachinin A supplier, Amyloid, inhibitors, activators

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