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BAPTA

Cat. No. M4944
BAPTA Structure
Size Price Availability Quantity
50mg USD 50  USD50 In stock
100mg USD 60  USD60 In stock
200mg USD 90  USD90 In stock
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Quality Control
Biological Activity

The presence of four carboxylic acid functional groups makes possible the binding of two calcium ions. The extensive flexibility of the carboxylate ligands is critical to the coordination of calcium and other metal ions.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 476.43
Formula C22H24N2O10
CAS Number 85233-19-8
Purity 99.74%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

[1] Xingzhi Jing, et al. Calcium chelator BAPTA‑AM protects against iron overload‑induced chondrocyte mitochondrial dysfunction and cartilage degeneration

[2] Kyu-Ree Kang, et al. BAPTA, a calcium chelator, neuroprotects injured neurons in vitro and promotes motor recovery after spinal cord transection in vivo

[3] Shuaishuai Wu, et al. Intracellular calcium chelating agent (BAPTA-AM) aids stallion semen cooling and freezing-thawing

[4] Hongmei Hu, et al. BAPTA-AM dramatically improves maturation and development of bovine oocytes from grade-3 cumulus-oocyte complexes

[5] Feng-Jun Li, et al. BAPTA-AM decreases cellular pH, inhibits acidocalcisome acidification and autophagy in amino acid-starved T. brucei

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