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Bambuterol hydrochloride

Cat. No. M3662
Bambuterol hydrochloride Structure
Synonym:

KWD-2183

Size Price Availability Quantity
Free Sample (0.5-1 mg)  USD 0 In stock
10mM*1mL in DMSO USD 65  USD65 In stock
5mg USD 40  USD40 In stock
10mg USD 60  USD60 In stock
50mg USD 95  USD95 In stock
100mg USD 120  USD120 In stock
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Quality Control & Documentation
Biological Activity

Bambuterol hydrochloride is an effective β -adrenergic receptor agonist.

Chemical Information
Molecular Weight 403.90
Formula C18H29N3O5.HCl
CAS Number 81732-46-9
Solubility (25°C) DMSO 80 mg/mL
Water 30 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Chou YL, et al. Eur Arch Otorhinolaryngol. Effects of bambuterol and terbutaline on isolated rat's tracheal smooth muscle.

[2] Bosak A, et al. Arch Biochem Biophys. Amino acid residues involved in stereoselective inhibition of cholinesterases with bambuterol.

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