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Baloxavir marboxil

Cat. No. M10163
Baloxavir marboxil Structure
Synonym:

S-033188; RG 6152

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 150  USD150 In stock
25mg USD 275  USD275 In stock
50mg USD 440  USD440 In stock
100mg USD 745  USD745 In stock
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Quality Control & Documentation
Biological Activity

Baloxavir marboxil is a novel cap-dependent endonuclease inhibitor for the treatment of influenza A and B virus infections.

Chemical Information
Molecular Weight 571.55
Formula C27H23F2N3O7S
CAS Number 1985606-14-1
Solubility (25°C) DMSO ≥ 60 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Keita Fukao, et al. J Antimicrob Chemother. Combination treatment with the cap-dependent endonuclease inhibitor baloxavir marboxil and a neuraminidase inhibitor in a mouse model of influenza A virus infection

[2] Paulina Koszalka, et al. Influenza Other Respir Viruses. Influenza antivirals currently in late-phase clinical trial

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Keywords: Baloxavir marboxil, S-033188; RG 6152 supplier, Anti-infection, inhibitors, activators


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