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Bakkenolide B

Cat. No. M40334
Bakkenolide B Structure
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Biological Activity

Bakkenolide B is isolated from petasites japonicas leaves and has anti-allergic and anti-inflammatory effects. Bakkenolide B can be used for the study of asthma.

Chemical Information
Molecular Weight 390.47
Formula C22H30O6
CAS Number 18455-98-6
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Shota Uesugi et al. Biosci Biotechnol Biochem. A yeast-based screening system identified bakkenolide B contained in Petasites japonicus as an inhibitor of interleukin-2 production in a human T cell line

[2] Hyun Sim Woo et al. Biomolecules. Bakkenolides and Caffeoylquinic Acids from the Aerial Portion of Petasites japonicus and Their Bacterial Neuraminidase Inhibition Ability

[3] Sun Young Park et al. Int J Mol Med. Petasites japonicus bakkenolide B inhibits lipopolysaccharide‑induced pro‑inflammatory cytokines via AMPK/Nrf2 induction in microglia

[4] Kyoung-Pil Lee et al. J Ethnopharmacol. Anti-allergic and anti-inflammatory effects of bakkenolide B isolated from Petasites japonicus leaves

[5] Fu-Jin Zhang et al. Phytother Res. Anti-allergic effects of total bakkenolides from Petasites tricholobus in ovalbumin-sensitized rats

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