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B-Raf IN 11 (ZINC72115182) is a selective B-RafV600E inhibitor (IC50=76 nM), shows selectivity for B-RafV600E over B-RafWT with selectivity of 3.1-fold. B-Raf IN 11 can be used in colorectal cancer research[1]
| Molecular Weight | 458.28 |
| Formula | C17H14BrF2N3O3S |
| CAS Number | 918504-27-5 |
| Form | Solid |
| Solubility (25°C) | DMSO 100 mg/mL (ultrasonic) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[3] Takamichi Ito, et al. Curr Treat Options Oncol. BRAF Heterogeneity in Melanoma
[5] Gaurav Mendiratta, et al. Nat Commun. Cancer gene mutation frequencies for the U.S. population
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