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B-HT 920 dihydrochloride

Cat. No. M5456
B-HT 920 dihydrochloride Structure

Talipexole dihydrochloride

Size Price Availability Quantity
10mg USD 100  USD100 In stock
50mg USD 400  USD400 In stock
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Quality Control & Documentation
Biological Activity

B-HT 920(Talipexole 2Hcl) is a dopamine D2 receptor agonist, α2-adrenoceptor agonist and 5-HT3 receptor antagonist, which displays antiParkinsonian activity.

Chemical Information
Molecular Weight 282.23
Formula C10H17Cl2N3S
CAS Number 36085-73-1
Solubility (25°C) 9.4 mg/mL in DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Johansen PA, et al. Life Sci. B-HT 920 stimulates postsynaptic D2 dopamine receptors in the normal rat: electrophysiological and behavioral evidence.

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Keywords: B-HT 920 dihydrochloride, Talipexole dihydrochloride supplier, Adrenergic Receptor, inhibitors, activators

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