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AZD4635

Cat. No. M7531
AZD4635 Structure
Synonym:

HTL1071

Size Price Availability Quantity
5mg USD 90  USD90 In stock
10mg USD 135  USD135 In stock
25mg USD 210  USD210 In stock
50mg USD 320  USD320 In stock
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Quality Control & Documentation
Biological Activity

AZD4635 is a novel adenosine 2A receptor (A2AR) inhibitor with a Ki of 1.7 nM.

Product Citations
Chemical Information
Molecular Weight 315.73
Formula C15H11ClFN5
CAS Number 1321514-06-0
Solubility (25°C) DMSO ≥ 42 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Alexandra Borodovsky, et al. Cancer Research Preclinical pharmacodynamics and antitumor activity of AZD4635, a novel adenosine 2A receptor inhibitor that reverses adenosine mediated T cell suppression

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  Catalog
Abmole Inhibitor Catalog




Keywords: AZD4635, HTL1071 supplier, Adenosine Receptor, inhibitors, activators


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