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AZD1656

Cat. No. M10305
AZD1656 Structure
Synonym:

AZD-1656

Size Price Availability Quantity
1mg USD 340  USD340 In stock
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Quality Control & Documentation
Biological Activity

AZD1656 is a potent, selective and orally active glucokinase (GK) activator, with an EC50 of 60 nM.

Chemical Information
Molecular Weight 478.51
Formula C24H26N6O5
CAS Number 919783-22-5
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Brian E Ford, et al. Diabetes Obes Metab. Chronic glucokinase activator treatment activates liver Carbohydrate response element binding protein and improves hepatocyte ATP homeostasis during substrate challenge

[2] Terri Mitchard, et al. Birth Defects Res B Dev Reprod Toxicol. The novel use of a heterozygous knockout mouse for embryofetal development assessment of a glucokinase activator

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MK-0941 free base 

MK-0941 free base is an orally active glucokinase activator, with EC50s of 240 and 65 nM for recombinant human glucokinase in the presence of 2.5 and 10 mM glucose, respectively. MK-0941 free base exhibits strong glucose-lowering activity and is a potential therapeutic agent for treatment of type 2 diabetes.

  Catalog
Abmole Inhibitor Catalog




Keywords: AZD1656, AZD-1656 supplier, Glucokinase (GK), inhibitors, activators


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