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AZ 10606120 dihydrochloride is a potent P2X7 receptor antagonist (KD values are 1.4 and 19 nM at human and rat P2X7 receptors respectively). Binds in a positive cooperative manner to sites distinct from, but coupled to, the ATP binding site and acts as a negative allosteric modulator. Inhibits tumor growth and displays antiangiogenic effects in mice.
| Molecular Weight | 495.48 |
| Formula | C25H34N4O2.2HCl |
| CAS Number | 607378-18-7 |
| Solubility (25°C) | DMSO 49.55 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Stasch, et al. Nature. NO-independent regulatory site on soluble guanylate cyclase.
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