Free shipping on all orders over $ 500

Avasopasem manganese

Cat. No. M30091

All AbMole products are for research use only, cannot be used for human consumption.

Avasopasem manganese Structure
Synonym:

GC-4419; M-40419

Price and Availability

For this product's availability, delivery time and price, please email [email protected] directly or click the "Inquiry Now" button below.

Quality Control & Documentation
Biological Activity

Avasopasem manganese (GC4419; M-40419) is a potent superoxide dismutase mimetic that rapidly and specifically converts O2*- to hydrogen peroxide (H2O2), arresting the initiation of this cascade. Avasopasem manganese can be used for the research of severe oral mucositis (SOM) and cancer.

Chemical Information
Molecular Weight 483.38
Formula C21H35Cl2MnN5
CAS Number 435327-40-5
Form Solid
Solubility (25°C) DMSO 50 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Stephen T Sonis, et al. Expert Opin Investig Drugs. Avasopasem for the treatment of radiotherapy-induced severe oral mucositis

[2] K A Mapuskar, et al. Redox Biol. Avasopasem manganese (GC4419) protects against cisplatin-induced chronic kidney disease: An exploratory analysis of renal metrics from a randomized phase 2b clinical trial in head and neck cancer patients

[3] Carryn M Anderson, et al. Int J Radiat Oncol Biol Phys. Two-Year Tumor Outcomes of a Phase 2B, Randomized, Double-Blind Trial of Avasopasem Manganese (GC4419) Versus Placebo to Reduce Severe Oral Mucositis Owing to Concurrent Radiation Therapy and Cisplatin for Head and Neck Cancer

[4] Brock J Sishc, et al. Sci Transl Med. Avasopasem manganese synergizes with hypofractionated radiation to ablate tumors through the generation of hydrogen peroxide

[5] Stephen T Sonis. Drug Des Devel Ther. Superoxide Dismutase as an Intervention for Radiation Therapy-Associated Toxicities: Review and Profile of Avasopasem Manganese as a Treatment Option for Radiation-Induced Mucositis

Related ROS Products
N-Acetyl-L-cysteine ethyl ester

N-Acetyl-L-cysteine ethyl ester exhibits enhanced cell permeability, and produce NAC and cysteine. N-Acetyl-L-cysteine ethyl ester increases circulating hydrogen sulfide (H2S) and can be used as an H2S producer.

Manganese(salen) chloride

Manganese(salen) chloride (EUK-8) is a superoxide dismutase and catalase mimetic, it is an antioxidant with oxyradical scavenging properties.

Magnoloside F

Magnoloside F is a natural compound that can be isolated from the Magnolia officinalis, and has antioxidant activity.
Porphyra 334 

Porphyra 334 is an antioxidative and anti-photoaging agent.
Photosensitizer-1 

Photosensitizer-1 is a photosensitizer.
  Catalog
Abmole Inhibitor Catalog




Keywords: Avasopasem manganese, GC-4419; M-40419 supplier, ROS, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
Get to Know Us
Customer Support
Resources
Contact Us

Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2024 AbMole BioScience. All Rights Reserved.