AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
|Solubility (25°C)||Water 100 mg/mL|
Powder -20°C 3 years ; 4°C 2 years
In solvent -80°C 6 months ; -20°C 1 month
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
|Related PD-1/PD-L1 Products|
PD-1/PD-L1-IN-33 is a PD-1/PD-L1 inhibitor.
PD-1/PD-L1-IN-31 is a PD-1/PD-L1 inhibitor (IC50=2.2 nM).
|PD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA is a potent programmed cell death 1 (PD-1) inhibitor.
PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1.
PD-1/PD-L1-IN-32 is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity.
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