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Cat. No. M20859
AUNP-12 Structure

Aur-012, Aurigene-012, Aurigene NP-12

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Biological Activity

AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.

Chemical Information
Molecular Weight 3261.55
Formula C142H226N40O48
CAS Number 1353563-85-5
Solubility (25°C) Water 100 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Ashten N Omstead, et al. Carcinogenesis. CSF-1R inhibitor, pexidartinib, sensitizes esophageal adenocarcinoma to PD-1 immune checkpoint blockade in a rat model

[2] Wenrong Zhao, et al. Small. M2-Like TAMs Function Reversal Contributes to Breast Cancer Eradication by Combination Dual Immune Checkpoint Blockade and Photothermal Therapy

[3] Yuanyuan Cheng, et al. ACS Nano. An Intelligent Biomimetic Nanoplatform for Holistic Treatment of Metastatic Triple-Negative Breast Cancer via Photothermal Ablation and Immune Remodeling

[4] Bogdan Musielak, et al. Molecules. CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?

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Keywords: AUNP-12, Aur-012, Aurigene-012, Aurigene NP-12 supplier, PD-1/PD-L1, inhibitors, activators

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