AUNP-12, a new immune checkpoint modulator, is an inhibitor of the PD-1 pathway.
Molecular Weight | 3261.55 |
Formula | C142H226N40O48 |
CAS Number | 1353563-85-5 |
Solubility (25°C) | Water 100 mg/mL |
Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
[4] Bogdan Musielak, et al. Molecules. CA-170 - A Potent Small-Molecule PD-L1 Inhibitor or Not?
Related PD-1/PD-L1 Products |
---|
PD-1/PD-L1-IN-33
PD-1/PD-L1-IN-33 is a PD-1/PD-L1 inhibitor. |
PD-1/PD-L1-IN-31
PD-1/PD-L1-IN-31 is a PD-1/PD-L1 inhibitor (IC50=2.2 nM). |
PD1-PDL1-IN 1 TFA
PD1-PDL1-IN 1 TFA is a potent programmed cell death 1 (PD-1) inhibitor. |
PD-L1-IN-2
PD-L1-IN-2 is a potential tumor immunological agent by inhibiting PD-L1. |
PD-1/PD-L1-IN-32
PD-1/PD-L1-IN-32 is a potent PD-1/PD-L1 inhibitor (IC50=2.4 nM), with anticancer activity. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2023 AbMole BioScience. All Rights Reserved.