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Atropine sulfate

Cat. No. M3225
Atropine sulfate Structure
Synonym:

Sulfatropinol

Size Price Availability Quantity
25mg USD 36  USD40 In stock
50mg USD 54  USD60 In stock
100mg USD 90  USD100 In stock
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Quality Control
Biological Activity

Atropine sulfate is a competitive muscarinic acetylcholine receptor antagonist. Atropine is a naturally occurring tropane alkaloid extracted from deadly nightshade (Atropa belladonna), Jimson weed (Datura stramonium), mandrake (Mandragora officinarum) and other plants of the family Solanaceae. Atropine is a competitive antagonist of the muscarinic acetylcholine receptors (acetylcholine being the main neurotransmitter used by the parasympathetic nervous system). Atropine dilates the pupils, increases heart rate, and reduces salivation and other secretions

Protocol
Cell Experiment
Cell lines
Preparation method
Concentrations
Incubation time
Animal Experiment
Animal models Male Sprague-Dawley rats
Formulation purified water
Dosages 1mg/5ml/kg
Administration administrated orally
Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.

Chemical Information
Molecular Weight 338.41
Formula C17H23NO3 . 1/2 H2SO4
CAS Number 55-48-1
Purity >98%
Solubility DMSO ≥ 10 mg/mL
Storage at -20°C
References

Determination of atropine sulfate using a novel sensitive DNA-biosensor based on its interaction on a modified pencil graphite electrode.
Ensafi AA, et al. Talanta. 2015 Jan;131:149-55. PMID: 25281086.

Effects of a dopamine receptor agonist and atropine sulfate on absorption of valproic acid in rats.
Kameya H, et al. Biomed Res. 2009 Apr;30(2):101-6. PMID: 19420733.

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: Atropine sulfate, Sulfatropinol supplier, AChR/AChE, inhibitors

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