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Asundexian

Cat. No. M21060

All AbMole products are for research use only, cannot be used for human consumption.

Asundexian Structure
Synonym:

BAY-2433334

Size Price Availability Quantity
1mg USD 190 In stock
5mg USD 475 In stock
10mg USD 660 In stock
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Quality Control & Documentation
Biological Activity

Asundexian (BAY2433334) is a reversible inhibitor of the active site of Factor XIa. Asundexian inhibits the activity of FXIa by directly, efficiently, and reversibly binding to its active site. the IC50 of human FXIa in Asundexian inhibition buffer is 1 nM.

Chemical Information
Molecular Weight 592.93
Formula C26H21ClF4N6O4
CAS Number 2064121-65-7
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Ashkan Shoamanesh, et al. Lancet. Factor XIa inhibition with asundexian after acute non-cardioembolic ischaemic stroke (PACIFIC-Stroke): an international, randomised, double-blind, placebo-controlled, phase 2b trial

[2] Sunil V Rao, et al. Circulation. A Multicenter, Phase 2, Randomized, Placebo-Controlled, Double-Blind, Parallel-Group, Dose-Finding Trial of the Oral Factor XIa Inhibitor Asundexian to Prevent Adverse Cardiovascular Outcomes After Acute Myocardial Infarction

[3] David Gailani. Lancet. Making anticoagulation safer

[4] Stefan Heitmeier, et al. J Thromb Haemost. Pharmacological profile of asundexian, a novel, orally bioavailable inhibitor of factor XIa

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Keywords: Asundexian, BAY-2433334 supplier, Factor Xa, inhibitors, activators

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