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AST2818 mesylate

Cat. No. M9400
AST2818 mesylate Structure
Synonym:

Alflutinib mesylate

Size Price Availability Quantity
5mg USD 215  USD215 In stock
10mg USD 320  USD320 In stock
50mg USD 900  USD900 In stock
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Quality Control & Documentation
Biological Activity

AST2818 mesylate is a third generation EGFR inhibitor that targets both EGFR activating mutations and T790M thus leading to tumor growth inhibition.

Chemical Information
Molecular Weight 664.7
Formula C29H35F3N8O5S
CAS Number 2130958-55-1
Solubility (25°C) DMSO ≥ 3 mg/mL (Need ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Y Shi, et al. J Thorac Oncol. Third Generation EGFR Inhibitor AST2818 (Alflutinib) in NSCLC Pat-ients with EGFR T790M Mutation: A phase1/2 Multi-Center Clinical Trial.

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Keywords: AST2818 mesylate, Alflutinib mesylate supplier, EGFR/HER2, inhibitors, activators

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