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Aspartic acid calcium

Cat. No. M14965
Aspartic acid calcium Structure
Synonym:

Calcium L-aspartate

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Biological Activity

Aspartic acid calcium (Calcium L-aspartate) is a chelate where calcium is attached to an amino acid naming L-Aspartic acid. L-Aspartic acid is an amino acid and serves as a building block for proteins in the body.

Chemical Information
Molecular Weight 171.16
CAS Number 10389-09-0
Solubility (25°C) Water ≥ 90 mg/mL
Storage 2-8°C, dry, sealed
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Teo Atz Dick, et al. A Polyplex in a Shell: The Effect of Poly(aspartic acid)-Mediated Calcium Carbonate Mineralization on Polyplexes Properties and Transfection Efficiency

[2] Tobias Lemke, et al. Three Reasons Why Aspartic Acid and Glutamic Acid Sequences Have a Surprisingly Different Influence on Mineralization

[3] Man Wang, et al. Investigating the calcium binding characteristics of black bean protein hydrolysate

[4] Elias Mulky, et al. Grafting of calcium chelating functionalities onto PLA monofilament fiber surfaces

[5] H Kozłowski, et al. 1H NMR studies on interactions of calcium and magnesium with aspartic acid and asparagine

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