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ASK120067

Cat. No. M13437

All AbMole products are for research use only, cannot be used for human consumption.

ASK120067 Structure
Synonym:

Limertinib

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Quality Control & Documentation
Biological Activity

ASK120067 is the third generation EGFR-TKI for non-small cell lung cancer (NSCLC) studies and is an effective oral EGFRT790M inhibitor (IC50 = 0.3 nM) with EGFRWT selectivity (IC50 = 6.0 nM).

Chemical Information
Molecular Weight 546.07
Formula C29H32ClN7O2
CAS Number 1934259-00-3
Solubility (25°C) DMSO : 41.67 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Yuankai Shi, et al. J Thorac Oncol. Efficacy and Safety of Limertinib (ASK120067) in Patients With Locally Advanced or Metastatic EGFR Thr790Met-Mutated NSCLC: A Multicenter, Single-Arm, Phase 2b Study

[2] Xinge Cui, et al. J Chromatogr B Analyt Technol Biomed Life Sci. Development of an LC-MS/MS method for quantifying ASK120067, a novel mutant-selective inhibitor of the epidermal growth factor receptor (EGFR) as well as its main metabolite in human plasma and its application in a pharmacokinetic study

[3] Tao Zhang, et al. Mol Cancer. Discovery of a novel third-generation EGFR inhibitor and identification of a potential combination strategy to overcome resistance

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Keywords: ASK120067 , Limertinib supplier, EGFR/HER2, inhibitors, activators

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