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Asiaticoside is effective in vitro and in vivo in inducing apoptosis and enhancing anti-tumour activity. Asiaticoside treatment may have beneficial effects in hyperpigmentation diseases or for skin whitening. Asiaticosides could inhibit TGF-beta expression, significantly decrease the synthesis and secretion of extracellular matrix, further inhibit the post-stenting intima-media membrane hyperplasia and reduce the endothelial cell damage by effectively up-regulate the expression of Smad7 protein. In vivo studies demonstrated that Asiaticoside could attenuate neurobehavioral, neurochemical and histological changes in transient focal middle cerebral artery occlusion animals. In addition, Asiaticoside showed anxiolytic effects in acute and chronic stress animals. Pretreatment with Asiaticoside decreased neuronal cell loss in a concentration-dependent manner and restored changes in expression of apoptotic-related proteins Bcl-2 and Bax. In cultured neurons, Asiaticoside significantly inhibited Ca(2+) influx induced by N-methyl-D-aspartate.
| Molecular Weight | 959.12 |
| Formula | C48H78O19 |
| CAS Number | 16830-15-2 |
| Solubility (25°C) | DMSO 30 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Qi FY, et al. Neural Regen Res. Neuroprotective effects of Asiaticoside.
[4] Al-Saeedi FJ. BMC Cancer. Study of the cytotoxicity of asiaticoside on rats and tumour cells.
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