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ARN1468 (compound 5) is an orally active and potent serpins inhibitor. ARN1468 can inhibit serpins activity would set the protease free to further reduce prion accumulation. ARN1468 shows anti-prion effect in ScGT1 RML, ScGT1 22L, ScN2a RML, and ScN2a 22L cell lines, with EC50 values of 8.64, 19.3, 11.2, and 6.27 μM.
| Molecular Weight | 354.33 |
| Formula | C16H17F3N4O2 |
| CAS Number | 1381459-14-8 |
| Storage | Please store the product under the recommended conditions in the Certificate of Analysis. |
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