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Cat. No. M21405
Arimoclomol Structure

BRX-220 free base

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Biological Activity

Arimoclomol (BRX-220 free base) is a heat shock protein (HSP) co-inducer. arimoclomol protects motor neurons by enhancing Hsp expression, thereby directly affecting protein aggregation and removing misfolded and misassembled proteins through the ubiquitin-proteasome system.

Chemical Information
Molecular Weight 313.78
Formula C14H20ClN3O3
CAS Number 289893-25-0
Solubility (25°C) N/A
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Anne-Katrin Guettsches, et al. Biomedicines. FYCO1 Increase and Effect of Arimoclomol-Treatment in Human VCP-Pathology

[2] Dominika Sitarska, et al. Metab Brain Dis. Treatment trials in Niemann-Pick type C disease

[3] Eugen Mengel, et al. J Inherit Metab Dis. Efficacy and safety of arimoclomol in Niemann-Pick disease type C: Results from a double-blind, randomised, placebo-controlled, multinational phase 2/3 trial of a novel treatment

[4] Bernadett Kalmar, et al. Pharmacol Ther. The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

[5] Veena Lanka, et al. Expert Opin Investig Drugs. Arimoclomol: a potential therapy under development for ALS

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Abmole Inhibitor Catalog

Keywords: Arimoclomol, BRX-220 free base supplier, HSP, inhibitors, activators

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