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Arimoclomol

Cat. No. M21405

All AbMole products are for research use only, cannot be used for human consumption.

Arimoclomol Structure
Synonym:

BRX-220 free base

Price and Availability

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Quality Control & Documentation
Biological Activity

Arimoclomol (BRX-220 free base) is a heat shock protein (HSP) co-inducer. arimoclomol protects motor neurons by enhancing Hsp expression, thereby directly affecting protein aggregation and removing misfolded and misassembled proteins through the ubiquitin-proteasome system.

Chemical Information
Molecular Weight 313.78
Formula C14H20ClN3O3
CAS Number 289893-25-0
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Anne-Katrin Guettsches, et al. Biomedicines. FYCO1 Increase and Effect of Arimoclomol-Treatment in Human VCP-Pathology

[2] Dominika Sitarska, et al. Metab Brain Dis. Treatment trials in Niemann-Pick type C disease

[3] Eugen Mengel, et al. J Inherit Metab Dis. Efficacy and safety of arimoclomol in Niemann-Pick disease type C: Results from a double-blind, randomised, placebo-controlled, multinational phase 2/3 trial of a novel treatment

[4] Bernadett Kalmar, et al. Pharmacol Ther. The role of heat shock proteins in Amyotrophic Lateral Sclerosis: The therapeutic potential of Arimoclomol

[5] Veena Lanka, et al. Expert Opin Investig Drugs. Arimoclomol: a potential therapy under development for ALS

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Keywords: Arimoclomol, BRX-220 free base supplier, HSP, inhibitors, activators

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