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arcyriarubin A

Cat. No. M3694
arcyriarubin A Structure

BIM-4, bisindolylmaleimide iv

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 320  USD320 In stock
50mg USD 960  USD960 In stock
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Quality Control & Documentation
Biological Activity

arcyriarubin A is a cell permeable protein kinase C (PKC) inhibitor. arcyriarubin A inhibits also protein kinase A (PKA).

Chemical Information
Molecular Weight 327.34
Formula C20H13N3O2
CAS Number 119139-23-0
Solubility (25°C) DMSO
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Takaaki Mizuoka, et al. Novel tryptophan metabolites, chromoazepinone A, B and C, produced by a blocked mutant of Chromobacterium violaceum, the biosynthetic implications and the biological activity of chromoazepinone A and B

[2] Kenichiro Saita, et al. Theoretical study of photophysical properties of bisindolylmaleimide derivatives

[3] Başak Kkrer Kaletaş, et al. Unexpected photophysical properties of symmetric indolylmaleimide derivatives

[4] Hans-Joachim Krmer, et al. Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A

[5] Min Huang, et al. Inhibition of nucleoside transport by protein kinase inhibitors

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Abmole Inhibitor Catalog

Keywords: arcyriarubin A, BIM-4, bisindolylmaleimide iv supplier, PKC, inhibitors, activators

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