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arcyriarubin A

Cat. No. M3694
arcyriarubin A Structure
Synonym:

BIM-4, bisindolylmaleimide iv

Size Price Availability Quantity
5mg USD 210  USD210 In stock
10mg USD 320  USD320 In stock
50mg USD 960  USD960 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

arcyriarubin A is a cell permeable protein kinase C (PKC) inhibitor. arcyriarubin A inhibits also protein kinase A (PKA).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 327.34
Formula C20H13N3O2
CAS Number 119139-23-0
Purity >98%
Solubility DMSO
Storage at -20°C
References

[1] Takaaki Mizuoka, et al. Novel tryptophan metabolites, chromoazepinone A, B and C, produced by a blocked mutant of Chromobacterium violaceum, the biosynthetic implications and the biological activity of chromoazepinone A and B

[2] Kenichiro Saita, et al. Theoretical study of photophysical properties of bisindolylmaleimide derivatives

[3] Başak Kkrer Kaletaş, et al. Unexpected photophysical properties of symmetric indolylmaleimide derivatives

[4] Hans-Joachim Krmer, et al. Pityriarubins, novel highly selective inhibitors of respiratory burst from cultures of the yeast Malassezia furfur: comparison with the bisindolylmaleimide arcyriarubin A

[5] Min Huang, et al. Inhibition of nucleoside transport by protein kinase inhibitors

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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: arcyriarubin A, BIM-4, bisindolylmaleimide iv supplier, PKC, inhibitors

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