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arcyriarubin A

Cat. No. M3694
arcyriarubin A Structure
Synonym:

BIM-4, bisindolylmaleimide iv

Size Price Availability Quantity
5mg USD 189  USD210 In stock
10mg USD 288  USD320 In stock
50mg USD 864  USD960 In stock
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Quality Control
  • Current batch:
  • Purity >98%
  • COA
  • MSDS
Biological Activity

arcyriarubin A is a cell permeable protein kinase C (PKC) inhibitor. arcyriarubin A inhibits also protein kinase A (PKA).

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight 327.34
Formula C20H13N3O2
CAS Number 119139-23-0
Purity >98%
Solubility DMSO
Storage at -20°C
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  Catalog
Abmole Inhibitor Catalog 2017




Keywords: arcyriarubin A, BIM-4, bisindolylmaleimide iv supplier, PKC, inhibitors

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