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AR-9281

Cat. No. M30879

All AbMole products are for research use only, cannot be used for human consumption.

AR-9281 Structure
Synonym:

APAU

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Quality Control & Documentation
Biological Activity

AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes.

Chemical Information
Molecular Weight 319.44
Formula C18H29N3O2
CAS Number 913548-29-5
Form Solid
Solubility (25°C) DMSO 25 mg/mL (ultrasonic)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Fangyu Du, et al. Eur J Med Chem. Discovery of memantyl urea derivatives as potent soluble epoxide hydrolase inhibitors against lipopolysaccharide-induced sepsis

[2] Yong Du, et al. EJNMMI Res. PET imaging of soluble epoxide hydrolase in non-human primate brain with [18F]FNDP

[3] Sanda Despa, et al. J Am Heart Assoc. Cardioprotection by controlling hyperamylinemia in a "humanized" diabetic rat model

[4] Kathleen Guglielmino, et al. Am J Physiol Heart Circ Physiol. Pharmacological inhibition of soluble epoxide hydrolase provides cardioprotection in hyperglycemic rats

[5] Sampath-Kumar Anandan, et al. Bioorg Med Chem Lett. 1-(1-acetyl-piperidin-4-yl)-3-adamantan-1-yl-urea (AR9281) as a potent, selective, and orally available soluble epoxide hydrolase inhibitor with efficacy in rodent models of hypertension and dysglycemia

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SWE101 

SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH.
trans-AUCB

trans-AUCB (t-AUCB) is a potent, orally active and selective soluble epoxide hydrolase (sEH) inhibitor with IC50s of 1.3 nM, 8 nM, 8 nM for hsEH, mouse sEH and rat sEH, respectively. trans-AUCB has anti-glioma activity.
  Catalog
Abmole Inhibitor Catalog




Keywords: AR-9281, APAU supplier, Epoxide Hydrolase, inhibitors, activators

All AbMole products are for research use only, cannot be used for human consumption or veterinary use. We do not provide products or services to individuals. Please comply with the intended use and do not use AbMole products for any other purpose.


 
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