All AbMole products are for research use only, cannot be used for human consumption.
TPPU is a potent soluble epoxide hydrolase (sEH) inhibitor (IC50 values are 1.1 and 2.1 nM for murine and human receptor, respectively). Inhibits MAPK and NF-κB signaling, as well as reducing ER stress and cell death in models of pancreatitis. Exhibits antidepressant effects in a social defeat stress model. Orally bioavailable and brain penetrant.
| Molecular Weight | 359.34 |
| Formula | C16H20F3N3O3 |
| CAS Number | 1222780-33-7 |
| Form | Solid |
| Solubility (25°C) | DMSO 35.93 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
| Related Epoxide Hydrolase Products |
|---|
| sEH inhibitor-16
sEH inhibitor-16 is a soluble epoxide hydrolase (sEH) inhibitors with an IC50 of 2 nM. |
| UC-1728
UC-1728 is a potent rabbit soluble epoxide hydrolase (sEH) inhibitor, with an IC50 of 2 nM on rabbit liver. |
| BI-1935
BI-1935 is a potent soluble epoxide hydrolase (sEH) inhibitor. BI-1935 can be used for the research of cardiovascular disease. |
| AR-9281
AR9281 (APAU) is a potent, selective and orally active soluble epoxide hydrolase (s-EH) inhibitor. AR-9281 can inhibits human sEH (HsEH) and murine sEH (MsEH) with IC50 values of 13.8 nM and 1.7 nM, respectively. AR9281 can be used for the research of inflammation, hypertension and type 2 diabetes. |
| SWE101
SWE101 (compound 22 b) is a potent soluble epoxide hydrolase (sEH)-P inhibitor with IC50s of 4 μM and 2.8 μM for human and rat sEH-P, respectively. SWE101 does not inhibit neither hydrolase nor phosphatase activity of the mouse sEH. |
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