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Cat. No. M6454
AR420626 Structure


Size Price Availability Quantity
5mg USD 118  USD118 In stock
10mg USD 190  USD190 In stock
25mg USD 380  USD380 In stock
50mg USD 620  USD620 In stock
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Quality Control & Documentation
Biological Activity

AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. AR420626 also suppresses serotonin-induced fecal output in rats.

Chemical Information
Molecular Weight 417.29
Formula C21H18Cl2N2O3
CAS Number 1798310-55-0
Solubility (25°C) DMSO 15 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.


[1] Abraham, et al. Bioorg Med Chem. New non competitive AMPA antagonists.

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Keywords: AR420626, AR-420626 supplier, GPR/FFAR, inhibitors, activators

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