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AR420626

Cat. No. M6454
AR420626 Structure
Synonym:

AR-420626

Size Price Availability Quantity
5mg USD 118  USD118 In stock
10mg USD 190  USD190 In stock
25mg USD 380  USD380 In stock
50mg USD 620  USD620 In stock
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Quality Control & Documentation
Biological Activity

AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. AR420626 also suppresses serotonin-induced fecal output in rats.

Chemical Information
Molecular Weight 417.29
Formula C21H18Cl2N2O3
CAS Number 1798310-55-0
Solubility (25°C) DMSO 15 mg/mL (ultrasonic and warming)
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
Conversion of different model animals based on BSA (PMID: 27057123)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

References

[1] Abraham, et al. Bioorg Med Chem. New non competitive AMPA antagonists.

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