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AR420626 is a selective agonist of free fatty acid receptor 3 (FFAR3, GPR41) with IC50 of 117 nM. AR420626 inhibits nicotine and serotonin induced changes in motility of isolated muscle strips from rat colon. AR420626 also suppresses serotonin-induced fecal output in rats.
| Molecular Weight | 417.29 |
| Formula | C21H18Cl2N2O3 |
| CAS Number | 1798310-55-0 |
| Solubility (25°C) | DMSO 15 mg/mL (ultrasonic and warming) |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
[1] Abraham, et al. Bioorg Med Chem. New non competitive AMPA antagonists.
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