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Apratastat

Cat. No. M8570

All AbMole products are for research use only, cannot be used for human consumption.

Apratastat Structure
Synonym:

TMI-005

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Quality Control & Documentation
Biological Activity

Apratastat (TMI-005) is an orally active, potent and selective dual inhibitor of disintegrin metalloenzyme 17 (ADAM17/ TACE) and matrix metalloprotease (MMP).

Chemical Information
Molecular Weight 414.5
Formula C17H22N2O6S2
CAS Number 287405-51-0
Solubility (25°C) DMSO: 20 mg/mL
Storage Powder          -20°C   3 years ;  4°C   2 years
In solvent       -80°C   6 months ;  -20°C   1 month
References

[1] Nathaniel L Lartey, et al. ADAM17/MMP inhibition prevents neutrophilia and lung injury in a mouse model of COVID-19

[2] Lynda Mezil, et al. Tumor selective cytotoxic action of a thiomorpholin hydroxamate inhibitor (TMI-1) in breast cancer

[3] Cathye Shu, et al. Pharmacokinetic-pharmacodynamic modeling of apratastat: a population-based approach

[4] Marcia L Moss, et al. Fluorescent substrates for the proteinases ADAM17, ADAM10, ADAM8, and ADAM12 useful for high-throughput inhibitor screening

[5] Mohamed M Thabet, et al. Drug evaluation: apratastat, a novel TACE/MMP inhibitor for rheumatoid arthritis

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Keywords: Apratastat, TMI-005 supplier, inhibitors, activators

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