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APD597 (JNJ-38431055) is a GPR119 agonist used in the study of type 2 diabetes mellitus. The EC50 of hGPR119 is 46 nM. APD597 was selected for preclinical development based on the good balance between agonist potency and intrinsic activity, especially its good solubility and potential to reduce compound - compound interactions.
| Molecular Weight | 479.55 |
| Formula | C21H29N5O6S |
| CAS Number | 897732-93-3 |
| Form | Solid |
| Solubility (25°C) | DMSO 90 mg/mL |
| Storage |
Powder -20°C 3 years ; 4°C 2 years In solvent -80°C 6 months ; -20°C 1 month |
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