|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
CHAPS is a non-denaturing, zwitterionic detergent that dissolves membrane proteins. CHAPS are used to stabilize various protein-DNA complexes and can preserve the biochemical activity of proteins in solution.
2-Aminoisobutyric acid is a rare, non-protein amino acid and end-product of pyrimidine metabolism, excreted in urine and found in some antibiotics of fungal origin.
Cyclohexanecarboxylic acid is a Valproate structural analogue with anticonvulsant action.
Doramectin is a macrocyclic lactone derivative of ivermectin, an anthelmintic that potentiates glutamate- and GABA-gated chloride channel opening in nematodes. It is used for the treatment and control of internal parasitosis, ticks and mange.
Ganciclovir sodium is an antiviral medication used to treat cytomegalovirus (CMV) infections
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