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Anti-human PD-1 mAb

Cat. No. M11385
Anti-human PD-1 mAb Structure
Size Price Availability Quantity
500μg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >95% , Endotoxin <0.01 EU/μg
  • COA
  • MSDS
Biological Activity

Expression host: CHO cells
Purity: >95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: <0.01 EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.

Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body. However, the tumor microenvironment will induce the infiltrating T cells to overexpress the PD-1 molecule, and the tumor cells will also overexpress the PD-L1 and PD-L2 ligands of PD-1, resulting in the continuous activation of the PD-1 pathway in the tumor microenvironment, resulting in the inhibition of THE FUNCTION of T cells. Antibodies against PD-1 that fail to kill tumor cells can block this pathway, thereby partially restoring the function of T cells and enabling T cells to continue to kill tumor cells. Therefore, anti-HUMAN PD-1 monoclonal antibody was used to "block" the amplified T cells in vitro, thus significantly improving the killing effect of immune cells on the tumor in patients.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >95% , Endotoxin <0.01 EU/μg
Solubility N/A
Storage 2-8℃
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