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Expression host: CHO cells
Purity: >95%. Sds-page gel and HIGH performance liquid chromatography were used
Endotoxin: <0.01 EU/μg
Storage and stability: stored at 2~8℃, valid for 24 months. In case of separate packaging, store in -20℃ storage period of 6 months, -80℃ storage period of 12 months, avoid repeated freeze-thaw.
Biological activity: PD-1 is mainly expressed in activated T cells and B cells, and its function is to inhibit cell activation, which is a normal self-stabilizing mechanism of the immune system. Because excessive T/B cell activation can cause autoimmune diseases, PD-1 is a talisman of our body. However, the tumor microenvironment will induce the infiltrating T cells to overexpress the PD-1 molecule, and the tumor cells will also overexpress the PD-L1 and PD-L2 ligands of PD-1, resulting in the continuous activation of the PD-1 pathway in the tumor microenvironment, resulting in the inhibition of THE FUNCTION of T cells. Antibodies against PD-1 that fail to kill tumor cells can block this pathway, thereby partially restoring the function of T cells and enabling T cells to continue to kill tumor cells. Therefore, anti-HUMAN PD-1 monoclonal antibody was used to "block" the amplified T cells in vitro, thus significantly improving the killing effect of immune cells on the tumor in patients.
| Storage | 2-8℃ |
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Products are for research use only. Not for human use. We do not sell to patients.
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