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Anti-human HER-2 mAb

Cat. No. M11384
Anti-human HER-2 mAb Structure
Size Price Availability Quantity
500μg USD 450  USD450 In stock
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Quality Control
  • Current batch:
  • Purity >98% , Endotoxin <2EU/mg
  • COA
  • MSDS
Biological Activity

Expression host: CHO cells
Endotoxin: <2EU/mg
Purity: > 98%
Concentration: 1 mg/mL
Storage and stability: stored at -20℃ for 6 months after opening, stored at -80℃ for 12 months. Avoid repeated freezing and thawing

Biological activity: HER2, also known as ErbB2, is a member of the human epidermal growth factor receptor family and plays an important role in signal transduction. Her-2/ NEU protein mediated signal transduction pathway mainly includes Ras/Raf/ mitin-activated protein kinase (MAPK) pathway and phosphatidylinositol pathway. 3 hydroxyl kinase (P13K)/Akt pathway, signal transduction and transcriptional activation (STAT) pathway and PLC pathway. 2 Expression of HER-2 / NEu protein in gastric cancer and its influencing factors Her-2/ NEu protein is usually only expressed in fetal period, and is only expressed at low level in very few tissues after adulthood.

Conversion of different model animals based on BSA (Value based on data from FDA Draft Guidelines)
Species Mouse Rat Rabbit Guinea pig Hamster Dog
Weight (kg) 0.02 0.15 1.8 0.4 0.08 10
Body Surface Area (m2) 0.007 0.025 0.15 0.05 0.02 0.5
Km factor 3 6 12 8 5 20
Animal A (mg/kg) = Animal B (mg/kg) multiplied by  Animal B Km
Animal A Km

For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.

Chemical Information
Molecular Weight
Formula
CAS Number
Purity >98% , Endotoxin <2EU/mg
Solubility N/A
Storage at -20°C
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