Free shipping on all orders over $ 500
Expression host: CHO cells
Endotoxin: <2EU/mg
Purity: > 98%
Concentration: 1 mg/mL
Storage and stability: stored at -20℃ for 6 months after opening, stored at -80℃ for 12 months. Avoid repeated freezing and thawing
Biological activity: HER2, also known as ErbB2, is a member of the human epidermal growth factor receptor family and plays an important role in signal transduction. Her-2/ NEU protein mediated signal transduction pathway mainly includes Ras/Raf/ mitin-activated protein kinase (MAPK) pathway and phosphatidylinositol pathway. 3 hydroxyl kinase (P13K)/Akt pathway, signal transduction and transcriptional activation (STAT) pathway and PLC pathway. 2 Expression of HER-2 / NEu protein in gastric cancer and its influencing factors Her-2/ NEu protein is usually only expressed in fetal period, and is only expressed at low level in very few tissues after adulthood.
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
| Molecular Weight | |
| Formula | |
| CAS Number | |
| Purity | >98% , Endotoxin <2EU/mg |
| Solubility | N/A |
| Storage | at -20°C |
| Related Cytokines Products |
|---|
| DKK-1 (Mammalian,N-8His)
Recombinant Human Dickkopf-related protein 1 is produced by our Mammalian expression system and the target gene encoding Thr32-His266 is expressed with a 8His tag at the N-terminus. |
| FGF-basic, Rat（E. coli）
FGF-basic, Rat（E. coli） Expressed with an n-terminal Gly. FGF-basic (Pro10-Ser154) Accession # P13109. Bioactivity: ED50 < 0.25 ng/ mL, measured by 3T3 cell proliferation method, corresponding to > 4.0 × 106 units /mg. |
| TNF-α, Human (E. coli)
TNF-α, Human (E. coli) Protein structure: TNF-α (VAL77-LEU233) Accession # P01375. Bioactivity: ED50 < 30.0 pg/ mL, measured in cytotoxicity assay of L-929 mouse fibrosarcoma cells in the presence of metabolic inhibitor actinomycin D, corresponding specific activity > 3.3 × 107 units /mg. |
| BMP-2, Human（E. coli）
BMP-2, Human（E. coli） Protein structure: BMP-2 (GLN283-ARG396) Accession # P12643. Biological activity: Experiment 1: To determine its ability to induce alkaline phosphatase production in ATDC-5 cells. The ED50 for this effect is generally 0.07-0.2µg/ mL. Experiment 2: The ability of inducing ALKALINE phosphatase production in C2C12 cells was determined. The ED50 for this effect is usually 0.2-1µg/ mL. |
| SCF, Human (P. pastoris)
SCF, Human (P. pastoris) The protein was Expressed with an n-terminal Met. SCF (Glu26-Ala189) Accession # P21583-1. Biological activity: ED50 was < 2.0 ng/ mL by dose-dependent tF-1 cell stimulation, corresponding specific activity was 5 × 105IU /mg. |
Products are for research use only. Not for human use. We do not sell to patients.
© Copyright 2010-2020 AbMole BioScience. All Rights Reserved.
