CD3 is an important marker of T cells, it is composed of five polypeptide chains: γ, δ, ε, ζ, and η. Mononuclear cells isolated from peripheral blood, bone marrow or cord blood can be cultured for a certain period of time in the presence of CD3 monoclonal antibodies and a variety of cytokines to obtain CIK (Cytokine-induced Killer) cells with tumor cell killing activity. The transmembrane region of the CD3 molecule is connected to the transmembrane region of the two peptide chains of the TCR through a salt bridge to form a TCR-CD3 complex, which jointly participates in the recognition of antigens by T cells. The activation signal generated by TCR recognition antigen is transduced into T cells by CD3.
| Solubility (25°C) | Water Saline PBS |
| Storage | 2-8°C for short term, -20°C for long term |
| Species | Mouse | Rat | Rabbit | Guinea pig | Hamster | Dog |
| Weight (kg) | 0.02 | 0.15 | 1.8 | 0.4 | 0.08 | 10 |
| Body Surface Area (m2) | 0.007 | 0.025 | 0.15 | 0.05 | 0.02 | 0.5 |
| Km factor | 3 | 6 | 12 | 8 | 5 | 20 |
| Animal A (mg/kg) = Animal B (mg/kg) multiplied by | Animal B Km |
| Animal A Km |
For example, to modify the dose of Compound A used for a mouse (20 mg/kg) to a dose based on the BSA for a rat, multiply 20 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for Compound A of 10 mg/kg.
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