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Anti-human CD3 mAb

Cat. No. M10111

All AbMole products are for research use only, cannot be used for human consumption.

Anti-human CD3 mAb Structure
Size Price Availability Quantity
500ug USD 245  USD245 In stock
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Quality Control & Documentation
  • Purity: ≥95%, Endotoxin ≤0.1EU/ug
  • COA
  • MSDS
Biological Activity

CD3 is an important marker of T cells, it is composed of five polypeptide chains: γ, δ, ε, ζ, and η. Mononuclear cells isolated from peripheral blood, bone marrow or cord blood can be cultured for a certain period of time in the presence of CD3 monoclonal antibodies and a variety of cytokines to obtain CIK (Cytokine-induced Killer) cells with tumor cell killing activity. The transmembrane region of the CD3 molecule is connected to the transmembrane region of the two peptide chains of the TCR through a salt bridge to form a TCR-CD3 complex, which jointly participates in the recognition of antigens by T cells. The activation signal generated by TCR recognition antigen is transduced into T cells by CD3.

Chemical Information
Solubility (25°C) Water
Saline
PBS
Storage 2-8°C for short term, -20°C for long term
References

[1] Rebecca S Goydel, et al. J Biol Chem. Affinity maturation, humanization, and co-crystallization of a rabbit anti-human ROR2 monoclonal antibody for therapeutic applications

[2] Siriwan Wansook, et al. Mol Immunol. Anti-human CD63 monoclonal antibody COS3A upregulates monocyte-induced IL-10 excretion leading to diminution of CD3-mediated T cell response

[3] Akira Iizuka, et al. Clin Cancer Res. A T-cell-engaging B7-H4/CD3-bispecific Fab-scFv Antibody Targets Human Breast Cancer

[4] Isabel Garcia Sousa, et al. BMC Res Notes. MicroRNA expression profiles in human CD3 + T cells following stimulation with anti-human CD3 antibodies

[5] C Transy, et al. Eur J Immunol. Most anti-human CD3 monoclonal antibodies are directed to the CD3 epsilon subunit

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Keywords: Anti-human CD3 mAb supplier, Cytokines and Growth Factors, inhibitors, activators

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