CD3 is an important marker of T cells, it is composed of five polypeptide chains: γ, δ, ε, ζ, and η. Mononuclear cells isolated from peripheral blood, bone marrow or cord blood can be cultured for a certain period of time in the presence of CD3 monoclonal antibodies and a variety of cytokines to obtain CIK (Cytokine-induced Killer) cells with tumor cell killing activity. The transmembrane region of the CD3 molecule is connected to the transmembrane region of the two peptide chains of the TCR through a salt bridge to form a TCR-CD3 complex, which jointly participates in the recognition of antigens by T cells. The activation signal generated by TCR recognition antigen is transduced into T cells by CD3.
|Body Surface Area (m2)||0.007||0.025||0.15||0.05||0.02||0.5|
|Animal A (mg/kg) = Animal B (mg/kg) multiplied by||Animal B Km|
|Animal A Km|
For example, to modify the dose of resveratrol used for a mouse (22.4 mg/kg) to a dose based on the BSA for a rat, multiply 22.4 mg/kg by the Km factor for a mouse and then divide by the Km factor for a rat. This calculation results in a rat equivalent dose for resveratrol of 11.2 mg/kg.
|Purity||≥95%, Endotoxin ≤0.1EU/ug|
|Storage||2-8°C for short term, -20°C for long term|
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